Background As the application of silica nanomaterials continues to expand, increasing
chances of its exposure to the human body and potential harm are anticipated. Although the
toxicity of silica nanomaterials is assumed to be affected by their physio-chemical properties,
including size and surface functionalization, its molecular mechanisms remain unclear. We
hypothesized that analysis of intracellular localization of the particles and subsequent
intracellular signaling could reveal a novel determinant of inflammatory response against …

CiNii 博士論文 - Size and surface modification of silica nanoparticles affect the severity of
lung toxicity by modulating endosomal ROS generation in macrophages … Size and
surface modification of silica nanoparticles affect the severity of lung toxicity by modulating
endosomal ROS generation in macrophages シリカナノ粒子の粒子径,および表面化学修飾は
マクロファージのエンドソーム内でのROS産生を調節する事で肺障害の重症度に影響する … Size
and surface modification of silica nanoparticles affect the severity of lung toxicity by …