This paper investigates the correlation between color quality and energy efficiency of indoor lighting control. The color quality, in terms of visual performance and comfort, is quantified using three measurements: illuminance, Color Rendering Index, and Correlated Color Temperature. Several experiments have been conducted to evaluate the potential energy savings of using different portions of light spectrum to obtain the optimal color quality. In particular, Light-Emitting Diodes are used as the lighting sources of the experimental luminaire. Moreover, the above quantification method and experimental results have been incorporated into a previously developed simulation framework for Building Automation and Control Systems, and smart lighting is used to adjust the tradeoff between comfort and energy consumption based on the presence of occupants. The results can be used to evaluate the viability of advanced lighting automation.