Social amoebae trap and kill bacteria by casting DNA nets
Extracellular traps (ETs) from neutrophils are reticulated nets of DNA decorated with anti-
microbial granules, and are capable of trapping and killing extracellular pathogens. Various
phagocytes of mammals and invertebrates produce ETs, however, the evolutionary history of
this DNA-based host defence strategy is unclear. Here we report that Sentinel (S) cells of the
multicellular slug stage of the social amoeba Dictyostelium discoideum produce ETs upon
stimulation with bacteria or lipopolysaccharide in a reactive oxygen species-dependent …
microbial granules, and are capable of trapping and killing extracellular pathogens. Various
phagocytes of mammals and invertebrates produce ETs, however, the evolutionary history of
this DNA-based host defence strategy is unclear. Here we report that Sentinel (S) cells of the
multicellular slug stage of the social amoeba Dictyostelium discoideum produce ETs upon
stimulation with bacteria or lipopolysaccharide in a reactive oxygen species-dependent …
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