Importance Sleep-wake disorders are a common and debilitating nonmotor manifestation of
Parkinson disease (PD), but treatment options are scarce. Objective To determine whether
nocturnal administration of sodium oxybate, a first-line treatment in narcolepsy, is effective
and safe for excessive daytime sleepiness (EDS) and disturbed nighttime sleep in patients
with PD. Design, Setting, and Participants Randomized, double-blind, placebo-controlled,
crossover phase 2a study carried out between January 9, 2015, and February 24, 2017. In a …