Solventless and metal-free regioselective hydrofluorination of functionalized alkynes and allenes: an efficient protocol for the synthesis of gem-difluorides
Z Lu, BS Bajwa, S Liu, S Lee, GB Hammond, B Xu - Green Chemistry, 2019 - pubs.rsc.org
Z Lu, BS Bajwa, S Liu, S Lee, GB Hammond, B Xu
Green Chemistry, 2019•pubs.rsc.orgThe combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-
12HF and KHSO4-13HF, generated a highly acidic fluorination system that facilitated
exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne
tethered drugs, or allenes to produce gem-difluorides with high atom economy, and with an
easy workup.
12HF and KHSO4-13HF, generated a highly acidic fluorination system that facilitated
exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne
tethered drugs, or allenes to produce gem-difluorides with high atom economy, and with an
easy workup.
The combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-12HF and KHSO4-13HF, generated a highly acidic fluorination system that facilitated exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne tethered drugs, or allenes to produce gem-difluorides with high atom economy, and with an easy workup.
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