Some novel insights on HPV16 related cervical cancer pathogenesis based on analyses of LCR methylation, viral load, E7 and E2/E4 expressions
D Das Ghosh, B Bhattacharjee, S Sen, L Premi… - 2012 - journals.plos.org
This study was undertaken to decipher the interdependent roles of (i) methylation within E2
binding site I and II (E2BS-I/II) and replication origin (nt 7862) in the long control region
(LCR),(ii) expression of viral oncogene E7,(iii) expression of the transcript (E7-E1∧ E4) that
encodes E2 repressor protein and (iv) viral load, in human papillomavirus 16 (HPV16)
related cervical cancer (CaCx) pathogenesis. The results revealed over-representation (p<
0.001) of methylation at nucleotide 58 of E2BS-I among E2-intact CaCx cases compared to …
binding site I and II (E2BS-I/II) and replication origin (nt 7862) in the long control region
(LCR),(ii) expression of viral oncogene E7,(iii) expression of the transcript (E7-E1∧ E4) that
encodes E2 repressor protein and (iv) viral load, in human papillomavirus 16 (HPV16)
related cervical cancer (CaCx) pathogenesis. The results revealed over-representation (p<
0.001) of methylation at nucleotide 58 of E2BS-I among E2-intact CaCx cases compared to …
[PDF][PDF] Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based
D Das Ghosh, B Bhattacharjee, S Sen, L Premi… - 2012 - academia.edu
This study was undertaken to decipher the interdependent roles of (i) methylation within E2
binding site I and II (E2BS-I/II) and replication origin (nt 7862) in the long control region
(LCR),(ii) expression of viral oncogene E7,(iii) expression of the transcript (E7-E1 'E4) that
encodes E2 repressor protein and (iv) viral load, in human papillomavirus 16 (HPV16)
related cervical cancer (CaCx) pathogenesis. The results revealed over-representation (p,
0.001) of methylation at nucleotide 58 of E2BS-I among E2-intact CaCx cases compared to …
binding site I and II (E2BS-I/II) and replication origin (nt 7862) in the long control region
(LCR),(ii) expression of viral oncogene E7,(iii) expression of the transcript (E7-E1 'E4) that
encodes E2 repressor protein and (iv) viral load, in human papillomavirus 16 (HPV16)
related cervical cancer (CaCx) pathogenesis. The results revealed over-representation (p,
0.001) of methylation at nucleotide 58 of E2BS-I among E2-intact CaCx cases compared to …
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