Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4
KN Ikeda, M Freeman - Journal of Biological Chemistry, 2019 - ASBMB
Rhomboid-like proteins are evolutionarily conserved, ubiquitous polytopic membrane
proteins, including the canonical rhomboid intramembrane serine proteases and also others
that have lost protease activity during evolution. We still have much to learn about their
cellular roles, and evidence suggests that some may have more than one function. For
example, RHBDL4 (rhomboid-like protein 4) is an endoplasmic reticulum (ER)–resident
protease that forms a ternary complex with ubiquitinated substrates and p97/VCP (valosin …
proteins, including the canonical rhomboid intramembrane serine proteases and also others
that have lost protease activity during evolution. We still have much to learn about their
cellular roles, and evidence suggests that some may have more than one function. For
example, RHBDL4 (rhomboid-like protein 4) is an endoplasmic reticulum (ER)–resident
protease that forms a ternary complex with ubiquitinated substrates and p97/VCP (valosin …