Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression
Kidneys possess one of the most intricate three-dimensional cellular structures in the body,
yet the spatial and molecular principles of kidney health and disease remain inadequately
understood. Here, we have generated high-quality datasets for 81 samples, including single
cell (sc), single nuclear (sn), spot level (Visium) and single cell resolution (CosMx) spatial
(sp)-RNA expression, and sn open chromatin, capturing cells from healthy, diabetic, and
hypertensive diseased human kidneys. By combining the snRNA, snATAC and scRNA …
yet the spatial and molecular principles of kidney health and disease remain inadequately
understood. Here, we have generated high-quality datasets for 81 samples, including single
cell (sc), single nuclear (sn), spot level (Visium) and single cell resolution (CosMx) spatial
(sp)-RNA expression, and sn open chromatin, capturing cells from healthy, diabetic, and
hypertensive diseased human kidneys. By combining the snRNA, snATAC and scRNA …
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