Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation
CG Hernandez-Coronado, A Guzman… - General and …, 2016 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) is a bioactive polar sphingolipid which stimulates
proliferation, growth and survival in various cell types. In the ovary S1P has been shown
protect the granulosa cells and oocytes from insults such as oxidative stress and
radiotherapy, and S1P concentrations are greater in healthy than atretic large follicles.
Hence, we postulate that S1P is fundamental in follicle development and that it is activated
in ovarian granulosa cells in response to FSH and VEGF. To test this hypothesis we set out …
proliferation, growth and survival in various cell types. In the ovary S1P has been shown
protect the granulosa cells and oocytes from insults such as oxidative stress and
radiotherapy, and S1P concentrations are greater in healthy than atretic large follicles.
Hence, we postulate that S1P is fundamental in follicle development and that it is activated
in ovarian granulosa cells in response to FSH and VEGF. To test this hypothesis we set out …