Spiral ganglion cell morphology in guinea pigs after deafening and neurotrophic treatment
MC van Loon, D Ramekers, MJH Agterberg… - Hearing research, 2013 - Elsevier
It is well known that spiral ganglion cells (SGCs) degenerate in hair-cell-depleted cochleas
and that treatment with exogenous neurotrophins can prevent this degeneration. Several
studies reported that, in addition, SGC size decreases after deafening and increases after
neurotrophic treatment. The dynamics of these cell size changes are not well known. In a
first experiment we measured size, shape (circularity) and intracellular density of SGCs in
guinea pigs at various moments after deafening (1, 2, 4, 6, and 8 weeks) and at various …
and that treatment with exogenous neurotrophins can prevent this degeneration. Several
studies reported that, in addition, SGC size decreases after deafening and increases after
neurotrophic treatment. The dynamics of these cell size changes are not well known. In a
first experiment we measured size, shape (circularity) and intracellular density of SGCs in
guinea pigs at various moments after deafening (1, 2, 4, 6, and 8 weeks) and at various …