[HTML][HTML] Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic
feature of chronic lymphocytic leukemia (CLL), irrespective of splicing factor mutation status,
which was associated with sensitivity to the spliceosome modulator, E7107. Splicing
modulation affected CLL survival pathways, including members of the B cell lymphoma-2
(BCL2) family of proteins, remodeling antiapoptotic dependencies of human and murine …
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic
feature of chronic lymphocytic leukemia (CLL), irrespective of splicing factor mutation status,
which was associated with sensitivity to the spliceosome modulator, E7107. Splicing
modulation affected CLL survival pathways, including members of the B cell lymphoma-2
(BCL2) family of proteins, remodeling antiapoptotic dependencies of human and murine …
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