Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility

M Weglage, S Ährlund-Richter, J Fuzik, V Skara… - bioRxiv, 2022 - biorxiv.org
Abstract The GPi-LHb pathway is the main output of the basal ganglia suggested to shape
motivated behaviors. We show here that Sst+ GPi-LHb neurons send direct feedback to key
nodes of the basal ganglia: the GPe, the striatal striosomes, and dopamine neurons in the
SNc. Chronic silencing of this pathway did not affect learning or execution of value-guided
choices, but severely disrupted the ability to adapt choice-behavior and seek an alternative
reward location after task reversal. Calcium imaging revealed that Sst+ GPi neurons did not …
Abstract
The GPi-LHb pathway is the main output of the basal ganglia suggested to shape motivated behaviors. We show here that Sst+ GPi-LHb neurons send direct feedback to key nodes of the basal ganglia: the GPe, the striatal striosomes, and dopamine neurons in the SNc. Chronic silencing of this pathway did not affect learning or execution of value-guided choices, but severely disrupted the ability to adapt choice-behavior and seek an alternative reward location after task reversal. Calcium imaging revealed that Sst+ GPi neurons did not signal outcome value or value updates during reversal learning. Instead, progressive suppression of the Sst+ GPi activity was linked to increased commitment to one choice, and activity increased during exploration of alternative choices. We propose that GPi Sst+ neurons drive behavioral flexibility through a direct feedback signal to balance the activity of key nodes in the basal ganglia.
biorxiv.org
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