Similar to other highly successful invasive bacterial pathogens, Staphylococcus aureus
recruits the complement regulatory protein factor H (fH) to its surface to inhibit the alternative
pathway of complement. Here, we report the identification of the surface-associated protein
SdrE as a fH-binding protein using purified fH overlay of S. aureus fractionated cell wall
proteins and fH cross-linking to S. aureus followed by mass spectrometry. Studies using
recombinant SdrE revealed that rSdrE bound significant fH whether from serum or as a …

Staphylococcus aureus surface protein SdrE binds the complement regulator factor H to
evade the immune response … Staphylococcus aureus surface protein SdrE binds the
complement regulator factor H to evade the immune response … Echague, Pamela S. Hair,
Michael D. Ward, Julius O. …