Protein aggregation into amyloid fibrils is a ubiquitous phenomenon across the spectrum of
neurodegenerative disorders and type 2 diabetes. A common strategy against
amyloidogenesis is to minimize the populations of toxic oligomers and protofibrils by
inhibiting protein aggregation with small molecules or nanoparticles. However, melanin
synthesis in nature is realized by accelerated protein fibrillation to circumvent accumulation
of toxic intermediates. Accordingly, we designed and demonstrated the use of star-shaped …