Stimulation for delivery of molecular therapy

MG Donovan, O Soykan, DC Deno, LJ Mulligan… - US Patent …, 2004 - Google Patents
The present invention addresses a number of problems existing in the prior art with respect
to controlled local delivery of angiogenic factors. Various embodiments of the present
invention provide Solutions and to one or more of the problems existing in the prior art with
respect to delivery of angiogenic factors. The present invention provides a novel electrical
pulse generator for angiogenesis and production angiogenic growth factors. The present
invention provides an electrical pulse gen erator for providing Subthreshold pulses. The …

Stimulation for delivery of molecular therapy

M Donovan, O Soykan, D Deno, L Mulligan… - US Patent App. 10 …, 2005 - Google Patents
… Subthreshold stimulation allows one to deliver electrical stimulation to the tissue to increase
the levels of angiogenic protein available without having the unwanted side effects due to the
stimulation of nerve or muscle cells, such as unwanted contraction and or uncomfortable
tactile sensations, and the like. … Subthreshold stimulation allows one to deliver electrical
stimulation to the tissue to increase the levels of angiogenic protein available without having
the unwanted side effects due to the stimulation of nerve or muscle cells, such as unwanted …
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