Strain rate imaging detects early cardiac effects of pegylated liposomal Doxorubicin as adjuvant therapy in elderly patients with breast cancer
R Jurcut, H Wildiers, J Ganame, J D'hooge… - Journal of the American …, 2008 - Elsevier
OBJECTIVE: Cardiac toxicity remains an important side effect of anthracyclines. New drug
formulations (eg, pegylated liposomal doxorubicin [PL-DOX]) seem to be a successful
strategy for reducing it. Changes in cardiac function induced by early chemotherapy,
however, are subtle and difficult to quantitate by conventional imaging methods. Doppler
myocardial imaging-based velocity, strain, and strain rate measurements have been shown
to sensitively quantify abnormalities in cardiac function in other settings. DESIGN: We …
formulations (eg, pegylated liposomal doxorubicin [PL-DOX]) seem to be a successful
strategy for reducing it. Changes in cardiac function induced by early chemotherapy,
however, are subtle and difficult to quantitate by conventional imaging methods. Doppler
myocardial imaging-based velocity, strain, and strain rate measurements have been shown
to sensitively quantify abnormalities in cardiac function in other settings. DESIGN: We …
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