Diabetic nephropathy is a major complication of diabetes and a leading cause of end-stage renal failure throughout much of the world. The synthetic drugs are effective in controlling the blood sugar but with many other complications. To overcome this, the need for natural products, which may be used as a dietary supplement to prevent diabetic nephropathy. Most drugs found to cause nephrotoxicity which exerts toxic effects by one or more common pathogenic mechanisms. Among them, Streptozotocin and Alloxan are the most frequently used drugs. Streptozotocin and Alloxan induced diabetic nephropathy in rodents offers relevant models to study the effect of natural products. The model has so far been used by many researchers to study the effect of drugs in diabetes. Natural products which include crude herbals, extracts, polyherbal formulations, herbo-mineral formulations, etc., have been used for the treatment of diabetes in the traditional system of medicine. In this review, we compiled several natural herbs that are used in the management of Streptozotocin and Alloxan induced diabetic nephropathy with their parameters evaluated.