过去一年中添加的文章,按日期排序

Impact of mutations in non-structural proteins on SARS-CoV-2 replication

EA Datsomor - 2024 - vtechworks.lib.vt.edu
27 天前 - … of the SARS-CoV-2 genome, notably within the spike protein, can impact transmission
… in the several NSPs including NSP1, 2, 3, 13,14, and 15 of the early Omicron (BA.1) …

AlphaFold2 Predictions of Conformational Ensembles and Atomistic Simulations of the SARS-CoV-2 Spike XBB Lineages Reveal Epistatic Couplings between …

N Raisinghani, M Alshahrani, G Gupta… - The Journal of …, 2024 - ACS Publications
69 天前 - … Computer simulation studies provided important atomistic insights into understanding
the dynamics of the SARS-CoV-2 S protein and the effects of Omicron mutations on …

[HTML][HTML] Emergence of SARS-CoV-2 Omicron Variant JN. 1 in Tamil Nadu, India-Clinical Characteristics and Novel Mutations

ST Selvavinayagam, S Sankar, YK Yong, A Murugesan… - medRxiv, 2024 - ncbi.nlm.nih.gov
82 天前 - Mutations within the spike protein sequences were … of SARS-CoV-2, to identify
the potential impact of these unique mutations on protein structure and possible functionality. …

Structures and stability of SARS-CoV-2 spike S2 subunit mutants targeting inter-subunit interactions

RJ Parsons, A Calloway, E Zhang, B Thakur… - Biophysical …, 2024 - cell.com
153 天前 - … studies have been performed on Omicron S protein, the individual effects of these
S2 … roles of S2 mutations in the SARS-CoV-2 spike and provides insights into how the spike

The Omicron XBB. 1 Variant and Its Descendants: Genomic Mutations, Rapid Dissemination and Notable Characteristics

R Giancotti, U Lomoio, B Puccio, G Tradigo, P Vizza… - Biology, 2024 - mdpi.com
160 天前 - … We examined the Omicron structure subvariants of the SARS-CoV-2 XBB spike
glycoprotein in 3 conformations: (i) spike glycoprotein in complex with ACE2 (1-up state) (PDB …

Novel engineered recombinant ACE2 reduces SARS-CoV-2-induced COVID-19 without cardiotoxic side effects

F Ávila-Moreno - Molecular Therapy, 2024 - cell.com
175 天前 - … 4 genetic mutations in key sites (H345/H374/H378/H505L) of the structural core of
ACE2’… derived from multiple SARS-CoV-2 variants (eg, Beta, Delta, and Omicron). Moreover, …

Mechanistic study of the transmission pattern of the SARSCoV2 omicron variant

K An, X Yang, M Luo, J Yan, P Xu… - … : Structure, Function …, 2024 - Wiley Online Library
188 天前 - … 2 (SARS-CoV-2) characterized by 30 mutations in its spike … Next, we investigated
the effect of specific single mutationsmutation of the omicron variant's spike protein. Of the 33 …

Dynamics of water-mediated interaction effects on the stability and transmission of Omicron

N Zaman, N Parvaiz, F Gul, R Yousaf, K Gul… - Scientific Reports, 2023 - nature.com
225 天前 - SARS-Cov-2 Omicron variant and its highly transmissible … and trimeric Cryo-EM
structures of spike protein in complex with … effect of mutations on stability and flexibility of spike

Evolution of the Omicron B. 1.1. 529 Sars-Cov-2 and its Variants in Tamil Nadu, India–a State-Wide Prospective Longitudinal Genomic Surveillance

S Suvaithenamudhan, YK Yong, H Kannan… - papers.ssrn.com
251 天前 - … The emergence of the omicron SARS-CoV-2 variant beholding many mutations,
especially in 87 the spike (S) protein severely threatens global health. With an aim to …

Treatment-Emergent Cilgavimab Resistance Was Uncommon in Vaccinated Omicron BA. 4/5 Outpatients

CEM Gruber, FG Tucci, M Rueca, V Mazzotta… - Biomolecules, 2023 - mdpi.com
267 天前 - Mutations in the SARS-CoV-2 Spike glycoprotein can affect monoclonal antibody
efficacy. Recent findings report the occurrence of resistant mutations … Complete SARS-CoV-2