Structural and kinetic studies of the human nudix hydrolase MTH1 reveal the mechanism for its broad substrate specificity
S Waz, T Nakamura, K Hirata, Y Koga-Ogawa… - Journal of biological …, 2017 - ASBMB
The human MutT homolog 1 (hMTH1, human NUDT1) hydrolyzes oxidatively damaged
nucleoside triphosphates and is the main enzyme responsible for nucleotide sanitization.
hMTH1 recently has received attention as an anticancer target because hMTH1 blockade
leads to accumulation of oxidized nucleotides in the cell, resulting in mutations and death of
cancer cells. Unlike Escherichia coli MutT, which shows high substrate specificity for 8-
oxoguanine nucleotides, hMTH1 has broad substrate specificity for oxidized nucleotides …
nucleoside triphosphates and is the main enzyme responsible for nucleotide sanitization.
hMTH1 recently has received attention as an anticancer target because hMTH1 blockade
leads to accumulation of oxidized nucleotides in the cell, resulting in mutations and death of
cancer cells. Unlike Escherichia coli MutT, which shows high substrate specificity for 8-
oxoguanine nucleotides, hMTH1 has broad substrate specificity for oxidized nucleotides …
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