Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation
The assembly of the autophagy initiation machinery nucleates autophagosome biogenesis,
including in the PINK1-and Parkin-dependent mitophagy pathway implicated in Parkinson's
disease. The structural interaction between the sole transmembrane autophagy protein,
autophagy-related protein 9A (ATG9A), and components of the Unc-51–like autophagy
activating kinase (ULK1) complex is one of the major missing links needed to complete a
structural map of autophagy initiation. We determined the 2.4-Å x-ray crystallographic …
including in the PINK1-and Parkin-dependent mitophagy pathway implicated in Parkinson's
disease. The structural interaction between the sole transmembrane autophagy protein,
autophagy-related protein 9A (ATG9A), and components of the Unc-51–like autophagy
activating kinase (ULK1) complex is one of the major missing links needed to complete a
structural map of autophagy initiation. We determined the 2.4-Å x-ray crystallographic …
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