Structural basis for the interaction between the potato virus X resistance protein (Rx) and its cofactor Ran GTPase-activating protein 2 (RanGAP2)
The potato (Solanum tuberosum) disease resistance protein Rx has a modular arrangement
that contains coiled-coil (CC), nucleotide-binding (NB), and leucine-rich repeat (LRR)
domains and mediates resistance to potato virus X. The Rx N-terminal CC domain
undergoes an intramolecular interaction with the Rx NB-LRR region and an intermolecular
interaction with the Rx cofactor RanGAP2 (Ran GTPase-activating protein 2). Here, we
report the crystal structure of the Rx CC domain in complex with the Trp-Pro-Pro (WPP) …
that contains coiled-coil (CC), nucleotide-binding (NB), and leucine-rich repeat (LRR)
domains and mediates resistance to potato virus X. The Rx N-terminal CC domain
undergoes an intramolecular interaction with the Rx NB-LRR region and an intermolecular
interaction with the Rx cofactor RanGAP2 (Ran GTPase-activating protein 2). Here, we
report the crystal structure of the Rx CC domain in complex with the Trp-Pro-Pro (WPP) …
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