Structural insights into the nucleotide base specificity of P2X receptors
P2X receptors are trimeric ATP-gated cation channels involved in diverse physiological
processes, ranging from muscle contraction to nociception. Despite the recent structure
determination of the ATP-bound P2X receptors, the molecular mechanism of the nucleotide
base specificity has remained elusive. Here, we present the crystal structure of zebrafish
P2X4 in complex with a weak affinity agonist, CTP, together with structure-based
electrophysiological and spectroscopic analyses. The CTP-bound structure revealed a …
processes, ranging from muscle contraction to nociception. Despite the recent structure
determination of the ATP-bound P2X receptors, the molecular mechanism of the nucleotide
base specificity has remained elusive. Here, we present the crystal structure of zebrafish
P2X4 in complex with a weak affinity agonist, CTP, together with structure-based
electrophysiological and spectroscopic analyses. The CTP-bound structure revealed a …
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