Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities
Yeast is an integral part of mammalian microbiome, and like commensal bacteria, has the
potential of being harnessed to influence immunity in clinical settings. However, functional
specificities of yeast-derived immunoregulatory molecules remain elusive. Here we find that
while under steady state, β-1, 3-glucan-containing polysaccharides potentiate pro-
inflammatory properties, a relatively less abundant class of cell surface polysaccharides,
dubbed mannan/β-1, 6-glucan-containing polysaccharides (MGCP), is capable of exerting …
potential of being harnessed to influence immunity in clinical settings. However, functional
specificities of yeast-derived immunoregulatory molecules remain elusive. Here we find that
while under steady state, β-1, 3-glucan-containing polysaccharides potentiate pro-
inflammatory properties, a relatively less abundant class of cell surface polysaccharides,
dubbed mannan/β-1, 6-glucan-containing polysaccharides (MGCP), is capable of exerting …
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