Structural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum
U Suttisansanee, K Lau, S Lagishetty, KN Rao… - Journal of Biological …, 2011 - ASBMB
The glyoxalase system catalyzes the conversion of toxic, metabolically produced α-
ketoaldehydes, such as methylglyoxal, into their corresponding nontoxic 2-
hydroxycarboxylic acids, leading to detoxification of these cellular metabolites. Previous
studies on the first enzyme in the glyoxalase system, glyoxalase I (GlxI), from yeast,
protozoa, animals, humans, plants, and Gram-negative bacteria, have suggested two metal
activation classes, Zn 2+ and non-Zn 2+ activation. Here, we report a biochemical and …
ketoaldehydes, such as methylglyoxal, into their corresponding nontoxic 2-
hydroxycarboxylic acids, leading to detoxification of these cellular metabolites. Previous
studies on the first enzyme in the glyoxalase system, glyoxalase I (GlxI), from yeast,
protozoa, animals, humans, plants, and Gram-negative bacteria, have suggested two metal
activation classes, Zn 2+ and non-Zn 2+ activation. Here, we report a biochemical and …
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