Structure of arterivirus nsp4: the smallest chymotrypsin-like proteinase with an α/β C-terminal extension and alternate conformations of the oxyanion hole
Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major
economic concern to the swine-and horse-breeding industries. The arterivirus replicase
gene encodes two large precursor polyproteins that are processed by the viral main
proteinase nonstructural protein 4 (nsp4). The three-dimensional structure of the 21-kDa
nsp4 from the arterivirus prototype equine arteritis virus has been determined to 2.0 Å
resolution. Nsp4 adopts the smallest known chymotrypsin-like fold with a canonical catalytic …
economic concern to the swine-and horse-breeding industries. The arterivirus replicase
gene encodes two large precursor polyproteins that are processed by the viral main
proteinase nonstructural protein 4 (nsp4). The three-dimensional structure of the 21-kDa
nsp4 from the arterivirus prototype equine arteritis virus has been determined to 2.0 Å
resolution. Nsp4 adopts the smallest known chymotrypsin-like fold with a canonical catalytic …
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