Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch
DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles
DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The
sliding clamp needs to be opened and installed onto DNA by a clamp loader ATPase of the
AAA+ family. The human clamp loader replication factor C (RFC) and sliding clamp
proliferating cell nuclear antigen (PCNA) are both essential and play critical roles in several
diseases. Despite decades of study, no structure of human RFC has been resolved. Here …
DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The
sliding clamp needs to be opened and installed onto DNA by a clamp loader ATPase of the
AAA+ family. The human clamp loader replication factor C (RFC) and sliding clamp
proliferating cell nuclear antigen (PCNA) are both essential and play critical roles in several
diseases. Despite decades of study, no structure of human RFC has been resolved. Here …
Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch
M Hedglin - 2020 - scholarsphere.psu.edu
DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles
DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The
sliding clamp needs to be opened and installed onto DNA by a clamp loader ATPase of the
AAA+ family. The human clamp loader replication factor C (RFC) and sliding clamp
proliferating cell nuclear antigen (PCNA) are both essential and play critical roles in several
diseases. Despite decades of study, no structure of human RFC has been resolved. Here …
DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The
sliding clamp needs to be opened and installed onto DNA by a clamp loader ATPase of the
AAA+ family. The human clamp loader replication factor C (RFC) and sliding clamp
proliferating cell nuclear antigen (PCNA) are both essential and play critical roles in several
diseases. Despite decades of study, no structure of human RFC has been resolved. Here …
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