Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms
M Giladi, SY Lee, Y Ariely, Y Teldan, R Granit… - Scientific Reports, 2017 - nature.com
Abstract Mammalian Na+/Ca2+ exchangers, NCX1 and NCX3, generate splice variants,
whereas NCX2 does not. The CBD1 and CBD2 domains form a regulatory tandem (CBD12),
where Ca2+ binding to CBD1 activates and Ca2+ binding to CBD2 (bearing the splicing
segment) alleviates the Na+-induced inactivation. Here, the NCX2-CBD12, NCX3-CBD12-B,
and NCX3-CBD12-AC proteins were analyzed by small-angle X-ray scattering (SAXS) and
hydrogen-deuterium exchange mass-spectrometry (HDX-MS) to resolve regulatory …
whereas NCX2 does not. The CBD1 and CBD2 domains form a regulatory tandem (CBD12),
where Ca2+ binding to CBD1 activates and Ca2+ binding to CBD2 (bearing the splicing
segment) alleviates the Na+-induced inactivation. Here, the NCX2-CBD12, NCX3-CBD12-B,
and NCX3-CBD12-AC proteins were analyzed by small-angle X-ray scattering (SAXS) and
hydrogen-deuterium exchange mass-spectrometry (HDX-MS) to resolve regulatory …
[PDF][PDF] structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms
Mammalian Na+/Ca2+ exchangers, NCX1 and NCX3, generate splice variants, whereas
NCX2 does not. The CBD1 and CBD2 domains form a regulatory tandem (CBD12), where
Ca2+ binding to CBD1 activates and Ca2+ binding to CBD2 (bearing the splicing segment)
alleviates the Na+-induced inactivation. Here, the NCX2-CBD12, NCX3-CBD12-B, and
NCX3-CBD12-AC proteins were analyzed by small-angle X-ray scattering (SAXS) and
hydrogen-deuterium exchange mass-spectrometry (HDX-MS) to resolve regulatory …
NCX2 does not. The CBD1 and CBD2 domains form a regulatory tandem (CBD12), where
Ca2+ binding to CBD1 activates and Ca2+ binding to CBD2 (bearing the splicing segment)
alleviates the Na+-induced inactivation. Here, the NCX2-CBD12, NCX3-CBD12-B, and
NCX3-CBD12-AC proteins were analyzed by small-angle X-ray scattering (SAXS) and
hydrogen-deuterium exchange mass-spectrometry (HDX-MS) to resolve regulatory …
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