Infrared (IR) spectroscopy of biomolecular ions combines mass spectrometry's high
sensitivity and ability to analyze complex mixtures with the enhanced structural information
available from vibrational spectroscopy. IR spectroscopy is in principle well placed to
distinguish isomers and allow chemical classification of unknown molecules. This review
gives an outline of current instrumentation, spectroscopic approaches, and potential
bottlenecks. We discuss the most promising applications in bioanalytical mass spectrometry …