In the present study, phytochemical and antimicrobial analysis of selected mangrove species: Suaeda nudiflora, Lumnitzera racemosa, Ipomoea tuba and Avicennia alba was performed. The phenol found in all selected mangroves and tannins found in the species: Suaeda nudiflora, Ipomoea tuba and Avicennia alba and terpenoids present in Lumnitzera racemosa, Ipomoea tuba and Avicenia alba. The steroids and emodins were not found in all selected mangrove species. The antioxidant analysis proved that maximum inhibitory potential of leaf extract was obtained in Lumnitzera racemosa and minimum scavenging activity was found in Suaeda nudiflora. The leaf extract with different solvents was screened for antibacterial activity against pathogenic strains: Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsella pneumonia and Bacillus subtilis. The methanol extracts from Squeeda nudiflora and Ipomoea tuba was shown highest zone of inhibition compared to other solvent extracts. The order of antimicrobial activity expressed as inhibitory zones of methanol > acetone > hexane observed for pathogenic strains. Further, thin layer chromatography (TLC) studies revealed presence of bioactive compounds in the extracts of the mangrove species.