Manual material handling (MMH) is unavoidable because of the nature of jobs or tasks as and man-machine interfaces in a construction worksystem. Data were collected from six strata of workers viz., masons, mason helpers, carpenters, welders, gas cutters and ground-level helpers (259 out of 700 workers) from a construction site of a steel plant located in India to analyze different types of occupational risk factors, such as awkward posture, repetitive movements and others associated with MMH activities to assess their impact on musculoskeletal disorders (MSDs). It is essential that these risk factors are required to be under control through application of ergonomics-based design approaches for construction worksystem. In this context, multinomial logistic regression analyses were used to identify the significant risk factors among the workers. The results shows that masons, mason helpers, carpenters, welders/gas cutters and ground-level helpers are greatly affected by static body posture, type of tools used, excessive stress due to repetition, awkward postures and extreme climate, respectively. Appropriate preventive and corrective measures are suggested for minimization of risks associated with such jobs/tasks to improve health and performance of the workers.