Study of some volatile compounds evolved from the thermal decomposition of atenolol

ACM Silva, DA Gálico, RB Guerra, AO Legendre… - Journal of Thermal …, 2014 - Springer
Journal of Thermal Analysis and Calorimetry, 2014Springer
Simultaneous thermogravimetry–differential scanning calorimetry (TG–DSC) and coupled
thermogravimetry–infrared spectroscopy (TG–FTIR) analyses were used to study the
antihypertensive drug atenolol. The TG–DSC curves provided information concerning the
thermal stability and decomposition profiles of the compound. From the TG–FTIR coupled
techniques, it was possible to identify ammonia and isopropylamine as possible volatile
compounds released during the thermal decomposition of the drug.
Abstract
Simultaneous thermogravimetry–differential scanning calorimetry (TG–DSC) and coupled thermogravimetry–infrared spectroscopy (TG–FTIR) analyses were used to study the antihypertensive drug atenolol. The TG–DSC curves provided information concerning the thermal stability and decomposition profiles of the compound. From the TG–FTIR coupled techniques, it was possible to identify ammonia and isopropylamine as possible volatile compounds released during the thermal decomposition of the drug.
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