Studying allosteric regulation in metal sensor proteins using computational methods
DK Chakravorty, KM Merz Jr - Advances in protein chemistry and structural …, 2014 - Elsevier
In this chapter, we describe advances made in understanding the mechanism of allosteric
regulation of DNA operator binding in the ArsR/SmtB family of metal-sensing proteins using
computational methods. The paradigm, zinc-sensing transcriptional repressor
Staphylococcus aureus CzrA represents an excellent model system to understand how
metal sensor proteins maintain cellular metal homeostasis. Here, we discuss studies that
helped to characterize a metal ion-mediated hydrogen-bonding pathway (HBP) that plays a …
regulation of DNA operator binding in the ArsR/SmtB family of metal-sensing proteins using
computational methods. The paradigm, zinc-sensing transcriptional repressor
Staphylococcus aureus CzrA represents an excellent model system to understand how
metal sensor proteins maintain cellular metal homeostasis. Here, we discuss studies that
helped to characterize a metal ion-mediated hydrogen-bonding pathway (HBP) that plays a …