Subcellular and regional localization of mRNA translation in midbrain dopamine neurons

BD Hobson, L Kong, MF Angelo, OJ Lieberman… - Cell reports, 2022 - cell.com
… investigate mRNA localization and translation within mDA neurons in the mouse brain.
Our results reveal the subcellular organization of protein synthesis in mDA neurons, with …

[图书][B] Subcellular Molecular Profiling of Midbrain Dopamine Neurons

BD Hobson - 2021 - search.proquest.com
… our understanding of dopamine neuronal cell biology by … the subcellular translatome and
proteome of dopamine neurons in … “Subcellular and regional localization of mRNA translation in …

Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function

M Matsumoto, CS Weickert, M Akil, BK Lipska… - Neuroscience, 2003 - Elsevier
… The regional distribution pattern of COMT mRNA in the … , enabling most of the ribosome to
initiate translation at this site. … The precise subcellular localization of MB-COMT remains an …

… of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human …

Y Yamamoto, K Takahata, M Kubota… - European Journal of …, 2023 - Springer
… We found a region-wise correlation between the mRNAmRNA localization and translation
in dopaminergic neurons of … study that examined the subcellular distribution of DAT in the rat …

Subcellular and regional localization of mRNA translation in midbrain dopamine neurons

E Herzog, B Hobson, L Kong, MF Angelo, O Lieberman… - 2021 - hal.science
… of central monoaminergic neurons, the subcellular localization of protein synthesis is not
well-… investigated mRNA localization and translation in midbrain dopaminergic (mDA) neurons, …

WNT signaling in midbrain dopaminergic neuron development and cell replacement therapies for Parkinson's disease

E Arenas, C Saltó, C Villaescusa - SpringerPlus, 2015 - Springer
… 3’-untranslated region (3’-UTR) of coding mRNA targets, interrupting translation and inducing
… for the proper localization of EB1 at the medial-distal region of the axon shaft in developing …

Subcellular proteomics of dopamine neurons in the mouse brain

BD Hobson, SJ Choi, EV Mosharov, RK Soni, D Sulzer… - Elife, 2022 - elifesciences.org
… and axonal proteomes of midbrain dopaminergic neurons. Our … have focused on mRNA
using translating ribosome affinity … region also included proteins enriched in specific subcellular

Developmental co-expression of Vglut2 and Nurr1 in a mes-di-encephalic continuum preceeds dopamine and glutamate neuron specification

S Dumas, Å Wallén-Mackenzie - Frontiers in Cell and Developmental …, 2019 - frontiersin.org
Midbrain dopamine (DA) neurons exist as several subtypes … Following regional specification
at the ventral midline of the … proteins show different subcellular localization depending of …

[HTML][HTML] Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease

P Kilfeather, JH Khoo, K Wagner, H Liang, MC Caiazza… - Cell Reports, 2024 - cell.com
… spatial transcriptomic and dopaminergic neuron translatomic … expression features of
dopaminergic neurons and 27 other … gene expression in brain cells in health, aging, and disease. …

Expression of the calmodulin-dependent protein phosphatase, calcineurin, in rat brain: developmental patterns and the role of nigrostriatal innervation

JW Polli, ML Billingsley, RL Kincaid - Developmental brain research, 1991 - Elsevier
… that CN protein and mRNA expression are subject to regional and … A total neuronal subcellular
fractionation was completed as de… Protein translation during early timepoints may be less …