Class II lanthipeptides belong to a diverse group of natural products known as ribosomally
synthesized and post-translationally modified peptides (RiPPs). Most RiPP precursor
peptides contain an N-terminal recognition sequence known as the leader peptide, which is
typically recognized by biosynthetic enzymes that catalyze modifications on the C-terminal
core peptide. For class II lanthipeptides, these are carried out by a bifunctional lanthipeptide
synthetase (LanM) that catalyzes dehydration and cyclization reactions on peptidic …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a diverse
class of peptides that are produced in the ribosome and subsequently undergo enzymatic
post translational modifications (PTMs). Class II lanthipeptides are one of such peptides.
Like many others, a class II lanthipeptide contains a N-terminal leader region for recognition
purposes and a C-terminal core region for enzymatic modifications. The modification of class
II lanthipeptides are by bifunctional lanthipeptide synthetase (LanM), which catalyzes both …