Successive relearning combines two effective learning techniques (retrieval practice and spaced practice) and involves practicing retrieval until some level of mastery has been reached (i.e., at least one correct retrieval attempt) in each of multiple sessions. Several laboratory studies have demonstrated the promise of successive relearning for enhancing student learning, but attempts to evaluate its effectiveness in authentic educational contexts are limited. In the current research, we implemented successive relearning in a difficult biopsychology course to examine its effectiveness at enhancing student learning on a high‐stakes exam. Students successively relearned some course content via a virtual flashcard program, whereas other course content was learned with business‐as‐usual activities. In two experiments, successive relearning boosted students' learning of course content by at least 10% (with ds ranging from 0.54 to 1.10). These findings suggest that implementing successive relearning in courses can be an effective method of promoting student achievement.