Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome (AIDS) drug candidate, targeting CD4 in lymphocytes

B Miao, M Geng, J Li, F Li, H Chen, H Guan… - Biochemical …, 2004 - Elsevier
Sulfated polymannuroguluronate (SPMG), a marine sulfated polysaccharide, has entered …
as the first anti-acquired immune deficiency syndrome (AIDS) drug candidate obtained from …

Sulfated polymannuroguluronate, a novel antiacquired immune deficiency syndrome drug candidate, blocks neuroinflammatory signalling by targeting the …

B Hui, W Xia, J Li, L Wang, J Ai… - Journal of …, 2006 - Wiley Online Library
… of severe CNS disorders classified as the human immunodeficiency virus-1 … sulfated
polymannuroguluronate (SPMG), a novel anti-acquired immunodeficiency syndrome drug candidate

… polymannuroguluronate, a novel antiacquired immune deficiency syndrome drug candidate, decreased vulnerability of PC12 cells to human immunodeficiency virus …

B Hui, J Li, MY Geng - Journal of neuroscience research, 2008 - Wiley Online Library
… We herein report that sulfated polymannuroguluronate (SPMG), a novel anti-acquired
immunodeficiency syndrome drug candidate now in phase II clinical trial, significantly decreased …

Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, inhibits HIV-1 Tat-induced angiogenesis in Kaposi's sarcoma cells

CX Lu, J Li, YX Sun, X Qi, QJ Wang, XL Xin… - Biochemical …, 2007 - Elsevier
… , an angioproliferation disease, is a form of malignancy which occurs in elderly or
immunosuppressed patients, and is often associated with acquired immune deficiency syndrome

Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome (AIDS) drug candidate, targeting CD4 in lymphocytes.

MBC Miao BenChun, GMY Geng MeiYu, LJ Li Jing… - 2004 - cabidigitallibrary.org
Sulfated polymannuroguluronate (SPMG), a marine sulfated polysaccharide extracted from
… as the first anti-acquired immune deficiency syndrome (AIDS) drug candidate obtained from …

Potential anti-HIV agents from marine resources: an overview

TS Vo, SK Kim - Marine drugs, 2010 - mdpi.com
… Therefore, it is essential to isolate novel anti-HIV therapeutics … a novel candidate for the
development of anti-HIV-1 agents. … of marine sulfated polymannuroguluronate interfering with HIV…

Potentiation of T cell function by a marine algae-derived sulfated polymannuroguluronate: in vitro analysis of novel mechanisms

W Xia, J Li, M Geng, X Xin, J Ding - Journal of pharmacological …, 2005 - jstage.jst.go.jp
immunodeficiency virus (SIV) (6). SPMG has been approved as an anti-acquired immune
deficiency syndrome (AIDS) candidate, … The mechanisms of action underlying the anti-HIV-1 …

Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KKR spatial triad

Y Wu, J Ai, J Zhao, B Xiong, X Xin, M Geng… - Acta Pharmacologica …, 2011 - nature.com
Sulfated polymannuroguluronate (SPMG), a candidate anti-AIDS drug, inhibited HIV replication
and interfered with HIV entry into host T lymphocytes. SPMG has high binding affinity for …

Marine glycan–based antiviral agents in clinical or preclinical trials

C Hao, G Yu, Y He, C Xu, L Zhang… - Reviews in medical …, 2019 - Wiley Online Library
… .24, 25 In addition, sulfated polymannuroguluronate (SPMG), a … great potential to be developed
into novel antiviral drugs. … -515) may be a novel anti-HIV candidate with low toxicity and …

T-cell receptor (TCR)/CD3 is involved in sulfated polymannuroguluronate (SPMG)-induced T lymphocyte activation

B Miao, J Li, X Fu, J Ding, M Geng - International immunopharmacology, 2005 - Elsevier
Sulfated polymannuroguluronate (SPMG) has entered the Phase II clinical trial as the first
anti-acquired immune deficiency syndrome (AIDS) drug candidate in China. Proliferation …