… Sulfated Lewis X trisaccharide 2b exists as a natural analogue of sLe X 1 and shows
superior binding to selectins. This paper describes the synthesis of sulfonic acid analogues
of the sLe X tetrasaccharide in which the sialic acid is replaced by an anomeric
sulfonomethyl-type sugar moiety. The sulfonic acid analogue, being a stronger acid than its
carboxylic counterpart, might bind effectively to the bioreceptors. Moreover, it should be
resistant against esterases. …