Supercharged green fluorescent protein delivers HPV16E7 DNA and protein into mammalian cells in vitro and in vivo
F Motevalli, A Bolhassani, S Hesami, S Shahbazi - Immunology Letters, 2018 - Elsevier
Macromolecules including DNA and proteins serve as important human therapeutics but are
limited by their general inability to cross cell membranes. Supercharged proteins have been
known as potent tools for delivery of macromolecules into mammalian cells. Thus, the use of
these delivery systems is important to reduce the human papillomavirus (HPV)-associated
malignancies through improvement of vaccine modalities. In this study, we used a
supercharged green fluorescent protein (+ 36 GFP) for delivery of the full-length HPV16 E7 …
limited by their general inability to cross cell membranes. Supercharged proteins have been
known as potent tools for delivery of macromolecules into mammalian cells. Thus, the use of
these delivery systems is important to reduce the human papillomavirus (HPV)-associated
malignancies through improvement of vaccine modalities. In this study, we used a
supercharged green fluorescent protein (+ 36 GFP) for delivery of the full-length HPV16 E7 …
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