Suppression of NF-κB and NF-κB regulated oxidative stress and neuroinflammation by BAY 11-7082 (IκB phosphorylation inhibitor) in experimental diabetic …
Inflammation is an emerging patho-mechanism of diabetes and its complications. NF-κB
pathway is one of the central machinery initiating and propagating inflammatory responses.
The present study envisaged the involvement of NF-κB inflammatory cascade in the
pathophysiology of diabetic neuropathy using BAY 11-7082, an IκB phosphorylation
inhibitor. Streptozotocin was used to induce diabetes in Sprauge Dawley rats. BAY 11-7082
(1 & 3 mg/kg) was administered to diabetic rats for 14 days starting from the end of six weeks …
pathway is one of the central machinery initiating and propagating inflammatory responses.
The present study envisaged the involvement of NF-κB inflammatory cascade in the
pathophysiology of diabetic neuropathy using BAY 11-7082, an IκB phosphorylation
inhibitor. Streptozotocin was used to induce diabetes in Sprauge Dawley rats. BAY 11-7082
(1 & 3 mg/kg) was administered to diabetic rats for 14 days starting from the end of six weeks …
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