Suppression of hepatocellular carcinoma by mycophenolic acid in experimental models and in patients

K Chen, J Sheng, B Ma, W Cao, PY Hernanda… - …, 2019 - journals.lww.com
Background. Tumor recurrence is a major complication following liver transplantation (LT) as
treatment for hepatocellular carcinoma (HCC). Immunosuppression is an important risk
factor for HCC recurrence, but conceivably may depend on the type of immunosuppressive
medication. Mycophenolic acid (MPA) is a currently widely used immunosuppressant. This
study investigated the effects of MPA on HCC. Methods. Three human HCC cell lines and
organoids from mouse primary liver tumor were used as experimental models. MTT, Alamar …

Suppression of Hepatocellular Carcinoma by Mycophenolic Acid in Experimental Models and in Patients

PY Hernanda - 2019 - erepository.uwks.ac.id
Tumor recurrence is a major complication following liver transplantation (LT) as treatment for
hepatocellular carcinoma (HCC). Immunosuppression is an important risk factor for HCC
recurrence, but conceivably may depend on the type of immunosuppressive medication.
Mycophenolic acid (MPA) is a currently widely used immunosuppressant. This study
investigated the effects of MPA on HCC. Methods. Three human HCC cell lines and
organoids from mouse primary liver tumor were used as experimental models. MTT, Alamar …
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