inflammatory drugs and certain selective cyclooxygenase (COX)-2 inhibitors may reduce the
relative risk of clinically evident prostate cancer. This prompted us to investigate the
chemopreventive potential of celecoxib, a selective COX-2 inhibitor, against prostate
carcinogenesis in a transgenic adenocarcinoma of the mouse prostate (TRAMP) model.
Similar to prostate cancer in humans, prostate malignancies in TRAMP mice progress from …