The strict nationwide lockdown imposed in India starting from 25^th March 2020 to prevent the spread of COVID-19 disease reduced the mobility and interrupted several important anthropogenic emission sources thereby creating a temporary air quality improvement. This study conducts a multi-scale (national-regional-city), multi-species, and multi-platform analysis of air pollutants and meteorological data by synergizing surface and satellite observations. Our analysis suggests a significant reduction in surface measurements of nitrogen dioxide (NO₂) (46–61 %) and fine particulate matter (PM_2.5) (42–60 %) during the lockdown period that are also corroborated by the reduction in satellite observed aerosol optical depth (AOD) (3–56 %) and tropospheric NO₂ column density (25–50 %) data over multiple cities. Other species, namely coarse particulate matter (PM₁₀) (24–62 %), ozone (22–56 %) also showed a substantial reduction whereas carbon monoxide (16–46 %), exhibited a moderate decline. In contrast, sulfur dioxide (SO₂) levels did not show any defined reduction trend but rather increased in Mumbai, Bengaluru, and Kolkata. The temporary air quality improvement achieved by the painful natural experiment of this pandemic has helped demonstrate the importance of reducing emissions from other sectors along with transportation and industry to achieve the national air quality targets in the future.