Sustainable radical approaches for cross electrophile coupling to synthesize trifluoromethyl-and allyl-substituted tert-alcohols
Trifluoromethylated molecules have gained privileged recognition among the medicinal and
pharmaceutical chemists. Sustainable photoredox-and electrochemical processes were
employed to facilitate the relatively less explored radical cross-electrophile coupling to
access trifluoromethyl-and allyl-substituted tert-alcohols. Reactions proceed through
trifluoromethyl ketyl radical and allyl radical intermediates, which undergo challenging
radical-radical cross-coupling. The developed transformations are mild and chemo-selective …
pharmaceutical chemists. Sustainable photoredox-and electrochemical processes were
employed to facilitate the relatively less explored radical cross-electrophile coupling to
access trifluoromethyl-and allyl-substituted tert-alcohols. Reactions proceed through
trifluoromethyl ketyl radical and allyl radical intermediates, which undergo challenging
radical-radical cross-coupling. The developed transformations are mild and chemo-selective …
Sustainable Radical Approaches for Cross Electrophile Coupling to Synthesize Trifluoromethyl- and Allyl- tert-Alcohols
MA Ashraf, Y Lee, N Iqbal, N Iqbal, EJ Cho - papers.ssrn.com
Trifluoromethyl molecules have gained privileged recognition among the medicinal and
pharmaceutical chemists. Sustainable photoredox-and electrochemical processes were
employed to facilitate the relatively less explored radical cross electrophile coupling to
access trifluoromethyl-and allyl-tertiary alcohols. Reactions proceed through trifluoromethyl
ketyl radical and allyl radical intermediates which undergo challenging cross radical-radical
coupling. The developed transformations are mild and chemo-selective to give cross …
pharmaceutical chemists. Sustainable photoredox-and electrochemical processes were
employed to facilitate the relatively less explored radical cross electrophile coupling to
access trifluoromethyl-and allyl-tertiary alcohols. Reactions proceed through trifluoromethyl
ketyl radical and allyl radical intermediates which undergo challenging cross radical-radical
coupling. The developed transformations are mild and chemo-selective to give cross …
以上显示的是最相近的搜索结果。 查看全部搜索结果