Sustained T cell immunity, protection and boosting using extended dosing intervals of BNT162b2 mRNA vaccine
Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was
introduced in the UK to accelerate population coverage with a single dose. In a study of 503
healthcare workers, we show that after priming following the first vaccine there is a marked
decline in SARS-CoV-2 neutralizing antibody (NAb) levels, but, in contrast, a sustained T
cell response to spike protein. This divergent immune profile was accompanied by robust
protection from infection over this period from the circulating alpha (B. 1.1. 7) variant …
introduced in the UK to accelerate population coverage with a single dose. In a study of 503
healthcare workers, we show that after priming following the first vaccine there is a marked
decline in SARS-CoV-2 neutralizing antibody (NAb) levels, but, in contrast, a sustained T
cell response to spike protein. This divergent immune profile was accompanied by robust
protection from infection over this period from the circulating alpha (B. 1.1. 7) variant …
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