Syndecan‐2 expression enhances adhesion and proliferation of stably transfected Swiss 3T3 cells
Cell biology international, 2003•Wiley Online Library
Syndecans (heparan sulfate proteoglycans) participate in cell—cell and cell—matrix
adhesion and are co‐and low‐affinity receptors for growth factors and enzymes,
respectively. We examined the influence of stable syndecan‐2 expression in Swiss 3T3 cells
on cell‐adhesion and proliferation. Higher syndecan‐2 expression changed cell
morphology and increased spreading and adhesion in these cells and proliferation induced
by FCS and FGF‐2. This emphasizes the role of syndecan‐2 in the integration of signals …
adhesion and are co‐and low‐affinity receptors for growth factors and enzymes,
respectively. We examined the influence of stable syndecan‐2 expression in Swiss 3T3 cells
on cell‐adhesion and proliferation. Higher syndecan‐2 expression changed cell
morphology and increased spreading and adhesion in these cells and proliferation induced
by FCS and FGF‐2. This emphasizes the role of syndecan‐2 in the integration of signals …
Abstract
Syndecans (heparan sulfate proteoglycans) participate in cell—cell and cell—matrix adhesion and are co‐ and low‐affinity receptors for growth factors and enzymes, respectively. We examined the influence of stable syndecan‐2 expression in Swiss 3T3 cells on cell‐adhesion and proliferation. Higher syndecan‐2 expression changed cell morphology and increased spreading and adhesion in these cells and proliferation induced by FCS and FGF‐2. This emphasizes the role of syndecan‐2 in the integration of signals from soluble and insoluble factors.
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