Synergistic coordination of chromatin torsional mechanics and topoisomerase activity
DNA replication in eukaryotes generates DNA supercoiling, which may intertwine (braid)
daughter chromatin fibers to form precatenanes, posing topological challenges during
chromosome segregation. The mechanisms that limit precatenane formation remain unclear.
By making direct torque measurements, we demonstrate that the intrinsic mechanical
properties of chromatin play a fundamental role in dictating precatenane formation and
regulating chromatin topology. Whereas a single chromatin fiber is torsionally soft, a braided …
daughter chromatin fibers to form precatenanes, posing topological challenges during
chromosome segregation. The mechanisms that limit precatenane formation remain unclear.
By making direct torque measurements, we demonstrate that the intrinsic mechanical
properties of chromatin play a fundamental role in dictating precatenane formation and
regulating chromatin topology. Whereas a single chromatin fiber is torsionally soft, a braided …
Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity
DNA replication in eukaryotes generates DNA supercoiling which may intertwine (braid)
daughter chromatin fibers to form precatenanes, posing topological challenges during
chromosome segregation. The mechanisms that limit precatenane formation remain unclear.
By making direct torque measurements, we demonstrate that the intrinsic mechanical
properties of chromatin play a fundamental role in dictating precatenane formation and
regulating chromatin topology. Whereas a single chromatin fiber is torsionally soft, a braided …
daughter chromatin fibers to form precatenanes, posing topological challenges during
chromosome segregation. The mechanisms that limit precatenane formation remain unclear.
By making direct torque measurements, we demonstrate that the intrinsic mechanical
properties of chromatin play a fundamental role in dictating precatenane formation and
regulating chromatin topology. Whereas a single chromatin fiber is torsionally soft, a braided …
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