[PDF][PDF] Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia
Background and Purpose: ALL is the most common pediatric cancer. The causes of the
majority of pediatric acute leukemia are unknown and are likely to involve an interaction
between genetic and environmental factors. Therefore, unfavourable gene-environmental
interactions might be involved in the genesis of ALL. The aim of this work was to evaluate, in
a case-control study, whether the common polymorphisms in 5, 10-
methylenetetrahydrofolate reductase (MTHFR) namely (C677T and A1298C) and …
majority of pediatric acute leukemia are unknown and are likely to involve an interaction
between genetic and environmental factors. Therefore, unfavourable gene-environmental
interactions might be involved in the genesis of ALL. The aim of this work was to evaluate, in
a case-control study, whether the common polymorphisms in 5, 10-
methylenetetrahydrofolate reductase (MTHFR) namely (C677T and A1298C) and …
Synergistic effect of methyltetrahydrofolate reductase [MTHFR] C677T and a1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia
K Azza M, M Heba S, E Gamal T, B Rong R, B Kishor G - 2007 - pesquisa.bvsalud.org
ABSTRACT ALL is the most common pediatric cancer. The causes of the majority of
pediatric acute leukemia are unknown and are likely to involve an interaction between
genetic and environmental factors. Therefore, unfavourable gene-environmental interactions
might be involved in the genesis of ALL. The aim of this work was to evaluate, in a case-
control study, whether the common polymorphisms in 5, 10-methylenetetrahydro-folate
reductase [MTHFR] namely [C677T and A1298C] and methionine synthase [MS][A2756G] …
pediatric acute leukemia are unknown and are likely to involve an interaction between
genetic and environmental factors. Therefore, unfavourable gene-environmental interactions
might be involved in the genesis of ALL. The aim of this work was to evaluate, in a case-
control study, whether the common polymorphisms in 5, 10-methylenetetrahydro-folate
reductase [MTHFR] namely [C677T and A1298C] and methionine synthase [MS][A2756G] …
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