Background Sustained cardiac adrenergic stimulation has been implicated in the
development and progression of heart failure. Release of norepinephrine is controlled by
negative feedback from presynaptic α2-adrenergic receptors, and the targets of the released
norepinephrine on myocytes are β1-adrenergic receptors. In transfected cells, a polymorphic
α2C-adrenergic receptor (α2CDel322–325) has decreased function, and a variant of the β1-
adrenergic receptor (β1Arg389) has increased function. We hypothesized that this …

Synergistic polymorphisms of β_1- and α_<2c>-adrenergic receptors and the risk of
congestive heart failure | CiNii Research … Synergistic polymorphisms of β_1- and α_<2c>-adrenergic
receptors and the risk of congestive heart failure …