using CODESSA III software. The dispiro [3H-indole-3, 2′-pyrrolidine-3′, 3′′-
piperidines] 24–48 were synthesized via [3+ 2]-cycloaddition reaction of azomethine
ylides,(generated in situ via decarboxylative condensation of isatins 21–23 with sarcosine)
and 3E, 5E-1-alkyl-3, 5-bis (arylmethylidene)-4-piperidones 10–20. Some of the synthesized
analogues exhibited promising antitumor properties against HELA (cervical), HEPG2 (liver) …