Synthesis, characterisation and biological activities of 2-methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate

TBSA Ravoof, KA Crouse, MIM Tahir, R Rosli… - Journal of Chemical …, 2011 - Springer
TBSA Ravoof, KA Crouse, MIM Tahir, R Rosli, DJ Watkin, FNF How
Journal of Chemical Crystallography, 2011•Springer
A new tridentate nitrogen–sulphur Schiff base has been synthesised from the condensation
of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate
(S2MBDTC). The Schiff base was characterized using various physico-chemical and
spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported.
The Schiff base crystallized in a monoclinic system with a space group of P 2 1/n, with crystal
cell parameters a= 10.8128 (2) Å, b= 9.3832 (2) Å, c= 18.0352 (4) Å, β= 97.1311 (9)°. The …
Abstract
A new tridentate nitrogen–sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor).
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